{"id":163,"date":"2011-08-30T13:21:00","date_gmt":"2011-08-30T13:21:00","guid":{"rendered":"http:\/\/lucasgferreira.wordpress.com\/2011\/08\/30\/local-injections-of-adipose-derived-mesenchymal-stem-cells-modulate-inflammation-and-increase-angiogenesis-ameliorating-the-dystrophic-phenotype-in-dystrophin-deficient-skeletal-muscle"},"modified":"2011-08-30T13:21:00","modified_gmt":"2011-08-30T13:21:00","slug":"local-injections-of-adipose-derived-mesenchymal-stem-cells-modulate-inflammation-and-increase-angiogenesis-ameliorating-the-dystrophic-phenotype-in-dystrophin-deficient-skeletal-muscle","status":"publish","type":"post","link":"https:\/\/blog.ufes.br\/lucasgf\/?p=163","title":{"rendered":"Local Injections of Adipose-Derived Mesenchymal Stem Cells Modulate Inflammation and Increase Angiogenesis Ameliorating the Dystrophic Phenotype in Dystrophin-Deficient Skeletal Muscle"},"content":{"rendered":"
Stem Cell Rev.<\/a> 2011 Aug 27. [Epub ahead of print]<\/div>\n

<\/h1>\n
da Justa Pinheiro CH<\/a>, de Queiroz JC<\/a>, Guimar\u00e3es-Ferreira L<\/a>, Vitzel KF<\/a>, Nachbar RT<\/a>, de Sousa LG<\/a>, de Souza-Jr AL<\/a>, Nunes MT<\/a>, Curi R<\/a>.<\/div>\n
\n

<\/h3>\n
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Av. Prof. Lineu Prestes, 1524 – Pr\u00e9dio Biom\u00e9dicas I – Cidade Universit\u00e1ria, Butant\u00e3, S\u00e3o Paulo\/SP, CEP:05508-900, Brazil, chjpinheiro@gmail.com.<\/span><\/div>\n
<\/div>\n
\n

Abstract<\/h3>\n

The effects of adipose-derived mesenchymal stem cells (ADMSC) transplantation on degeneration, regeneration and skeletal muscle function were investigated in dystrophin-deficient mice (24-week-old). ADMSC transplantation improved muscle strength and, resistance to fatigue. An increase in fiber cross-sectional area and in the number of fibers with centralized nuclei and augment of myogenin content were observed. In ADMSC-treated muscles a decrease in muscle content of TNF-\u03b1, IL-6 and oxidative stress measured by Amplex(\u00ae) reagent were observed. The level of TGF-\u03b21 was lowered whereas that of VEGF, IL-10 and IL-4 were increased by ADMSC treatment. An increase in markers of macrophage M1 (CD11 and F4-80) and a decrease in T lymphocyte marker (CD3) and arginase-1 were also observed in ADMSCs-treated dystrophic muscle. No change was observed in iNOS expression. Increased phosphorylation of Akt, p70S6k and 4E-BP1 was found in dystrophic muscles treated with ADMSC. These results suggest that ADMSC transplantation modulates inflammation and improves muscle tissue regeneration, ameliorating the dystrophic phenotype in dystrophin-deficient mice.<\/p><\/div>\n

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PMID: 21874281 [PubMed – as supplied by publisher] <\/dt>\n<\/dl>\n<\/div>\n
<\/div>\n","protected":false},"excerpt":{"rendered":"

Stem Cell Rev. 2011 Aug 27. [Epub ahead of print] da Justa Pinheiro CH, de Queiroz JC, Guimar\u00e3es-Ferreira L, Vitzel KF, Nachbar RT, de Sousa LG, de Souza-Jr AL, Nunes MT, Curi R. Department of Physiology and Biophysics, Institute of … Continue lendo →<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_uag_custom_page_level_css":"","footnotes":""},"categories":[21,27,34,36],"tags":[],"class_list":["post-163","post","type-post","status-publish","format-standard","hentry","category-fisiologia","category-musculo","category-paper","category-plasticidade-muscular"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false},"uagb_author_info":{"display_name":"Lucas Guimar\u00e3es Ferreira","author_link":"https:\/\/blog.ufes.br\/lucasgf\/?author=9"},"uagb_comment_info":1,"uagb_excerpt":"Stem Cell Rev. 2011 Aug 27. [Epub ahead of print] da Justa Pinheiro CH, de Queiroz JC, Guimar\u00e3es-Ferreira L, Vitzel KF, Nachbar RT, de Sousa LG, de Souza-Jr AL, Nunes MT, Curi R. Department of Physiology and Biophysics, Institute of … Continue lendo →","_links":{"self":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=163"}],"version-history":[{"count":0,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/163\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}