{"id":350,"date":"2012-02-28T15:45:06","date_gmt":"2012-02-28T17:45:06","guid":{"rendered":"http:\/\/blog.ufes.br\/lucasgf\/?p=350"},"modified":"2012-04-22T00:11:46","modified_gmt":"2012-04-22T02:11:46","slug":"suplementacao-com-leucina-promove-aumento-de-sintese-proteica-em-idosos","status":"publish","type":"post","link":"https:\/\/blog.ufes.br\/lucasgf\/?p=350","title":{"rendered":"Suplementa\u00e7\u00e3o com leucina promove aumento de s\u00edntese prot\u00e9ica em idosos"},"content":{"rendered":"
C<\/a>lin Nutr.<\/a>\u00a02012 Feb 20. [Epub ahead of print]<\/div>\n

Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein.<\/a><\/h2>\n

Casperson SL<\/a>,\u00a0Sheffield-Moore M<\/a>,\u00a0Hewlings SJ<\/a>,\u00a0Paddon-Jones D<\/a>.<\/span><\/h2>\n
\n
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.<\/span><\/em><\/h6>\n<\/div>\n
\n
Abstract<\/h6>\n

BACKGROUND & AIM:<\/strong>\u00a0Protein-energy supplementation is routinely employed to combat muscle loss. However, success is often compromised by increased satiety, poor palatability, high costs and low compliance.<\/span><\/h4>\n

METHODS:<\/strong>\u00a0For 2-weeks we supplemented meals of older individuals with leucine (4\u00a0g\/meal; 3 meals\/day; days 2-14). Metabolic studies were performed prior to (Day 1) and following (Day 15) supplementation. Leucine was not provided on metabolic study days. Venous blood and vastus lateralis muscle biopsies were obtained during a primed constant infusion of L-[ring-(13)C(6)] phenylalanine. Mixed muscle fractional synthesis rate (FSR), body composition and markers of nutrient signaling (mTOR, 4E-BP1 and p70S6K1 phosphorylation) were measured before and after a low protein\/carbohydrate simulated meal.<\/span><\/h4>\n

RESULTS:\u00a0<\/strong>The meal modestly increased FSR on Day 1 (postabsorptive: 0.063\u00a0\u00b1\u00a00.004 vs. postprandial: 0.075\u00a0\u00b1\u00a00.006%\/h; p\u00a0=\u00a00.03), however, two weeks of leucine supplementation increased postabsorptive FSR (p\u00a0=\u00a00.004) and the response to the meal (p\u00a0=\u00a00.01) (postabsorptive: 0.074\u00a0\u00b1\u00a00.007 vs. postprandial: 0.10\u00a0\u00b1\u00a00.007%\/h). Changes in FSR were mirrored by increased phosphorylation of mTOR, 4E-BP1 and p70S6K1 (p\u00a0\u2264\u00a00.1). No change in fat free mass was observed (p\u00a0>\u00a00.05).<\/span><\/h4>\n

CONCLUSIONS:\u00a0<\/strong>In older adults, leucine supplementation may improve muscle protein synthesis in response to lower protein meals.<\/span><\/span><\/p>\n

Copyright \u00c2\u00a9 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.<\/em><\/p>\n<\/div>\n

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\n
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PMID:\u00a022357161\u00a0[PubMed – as supplied by publisher]<\/span><\/dt>\n<\/dl>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Clin Nutr.\u00a02012 Feb 20. [Epub ahead of print] Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein. Casperson SL,\u00a0Sheffield-Moore M,\u00a0Hewlings SJ,\u00a0Paddon-Jones D. Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, … Continue lendo →<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_uag_custom_page_level_css":"","footnotes":""},"categories":[27,34,40],"tags":[],"class_list":["post-350","post","type-post","status-publish","format-standard","hentry","category-musculo","category-paper","category-suplementacao"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false},"uagb_author_info":{"display_name":"Lucas Guimar\u00e3es Ferreira","author_link":"https:\/\/blog.ufes.br\/lucasgf\/?author=9"},"uagb_comment_info":6,"uagb_excerpt":"Clin Nutr.\u00a02012 Feb 20. [Epub ahead of print] Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein. Casperson SL,\u00a0Sheffield-Moore M,\u00a0Hewlings SJ,\u00a0Paddon-Jones D. Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, … Continue lendo →","_links":{"self":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=350"}],"version-history":[{"count":7,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/350\/revisions"}],"predecessor-version":[{"id":392,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/350\/revisions\/392"}],"wp:attachment":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}