{"id":383,"date":"2012-04-21T12:58:24","date_gmt":"2012-04-21T14:58:24","guid":{"rendered":"http:\/\/blog.ufes.br\/lucasgf\/?p=383"},"modified":"2012-06-22T08:26:58","modified_gmt":"2012-06-22T10:26:58","slug":"suplementacao-com-hmb-atenua-perda-de-forca-e-massa-muscular-associada-ao-envelhecimento","status":"publish","type":"post","link":"https:\/\/blog.ufes.br\/lucasgf\/?p=383","title":{"rendered":"Suplementa\u00e7\u00e3o com HMB atenua perda de for\u00e7a e massa muscular associada ao envelhecimento"},"content":{"rendered":"
J Int Soc Sports Nutr.<\/a>\u00a02012 Apr 18;9(1):18. [Epub ahead of print]<\/div>\n

Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats.<\/h1>\n
Wilson\u00a0JM<\/a>,\u00a0Grant SC<\/a>,\u00a0Lee SR<\/a>,\u00a0Masad I<\/a>,\u00a0Park YM<\/a>,\u00a0Henning PC<\/a>,\u00a0Stout JR<\/a>,\u00a0Loenneke JP<\/a>,\u00a0Arjmandi BH<\/a>,\u00a0Panton LB<\/a>,\u00a0Kim JS<\/a>.<\/div>\n
\n

Abstract<\/h3>\n

ABSTRACT: Purpose To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions.<\/p>\n

METHODS:\u00a0Twelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat’s body composition and grip strength were assessed at baseline. Following, 6 young, 6 middle-aged, 5 old and 5 very old rats were sacrificed for baseline myofiber dimensions and gene transcript factor expression in the soleus (SOL) and gastrocnemius (GAS). The remaining 6 young and 5 old rats were given\u00a0HMB\u00a0for 16 wk. and then sacrificed.<\/span><\/span><\/p>\n

RESULTS:\u00a0Fat mass increased in the middle-aged control condition (+49%) but not the middle-aged\u00a0HMB\u00a0condition. In addition, fat mass declined (56%) in the old\u00a0HMB\u00a0condition but not the old control condition. Normalized strength declined and maintained respectively in the control and\u00a0HMB\u00a0conditions from 44 to 60 wk. and increased (+23%) (p < 0.05) from 86 to 102 wk. in only the\u00a0HMB\u00a0condition. Declines occurred in myofiber size in all muscles from 44 to 102 wk. in the control condition(10 to 15%), but not\u00a0HMB\u00a0condition. Atrogin-1 mRNA expression in the SOL and GAS muscles was greater in the 102-wk control condition than all other conditions: SOL (+45%) and GAS (+100%). This elevation was blunted by\u00a0HMB\u00a0in the 102 wk. old SOL. There was a condition effect in the SOL for myogenin, which significantly increased (+40%) only in the 102-wk.\u00a0HMB\u00a0group relative to the 44-wk. group.<\/span><\/h4>\n

<\/h4>\n

CONCLUSIONS:\u00a0HMB\u00a0may blunt age-related losses of strength and myofiber dimensions, possibly through attenuating the rise in protein breakdown.<\/span><\/h4>\n

 <\/p>\n

http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22512917<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

J Int Soc Sports Nutr.\u00a02012 Apr 18;9(1):18. [Epub ahead of print] Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats. Wilson\u00a0JM,\u00a0Grant SC,\u00a0Lee SR,\u00a0Masad I,\u00a0Park YM,\u00a0Henning PC,\u00a0Stout JR,\u00a0Loenneke JP,\u00a0Arjmandi BH,\u00a0Panton LB,\u00a0Kim JS. Abstract ABSTRACT: Purpose To … Continue lendo →<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_uag_custom_page_level_css":"","footnotes":""},"categories":[27,31,34,40],"tags":[],"class_list":["post-383","post","type-post","status-publish","format-standard","hentry","category-musculo","category-nutricao","category-paper","category-suplementacao"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false},"uagb_author_info":{"display_name":"Lucas Guimar\u00e3es Ferreira","author_link":"https:\/\/blog.ufes.br\/lucasgf\/?author=9"},"uagb_comment_info":3,"uagb_excerpt":"J Int Soc Sports Nutr.\u00a02012 Apr 18;9(1):18. [Epub ahead of print] Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats. Wilson\u00a0JM,\u00a0Grant SC,\u00a0Lee SR,\u00a0Masad I,\u00a0Park YM,\u00a0Henning PC,\u00a0Stout JR,\u00a0Loenneke JP,\u00a0Arjmandi BH,\u00a0Panton LB,\u00a0Kim JS. Abstract ABSTRACT: Purpose To … Continue lendo →","_links":{"self":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=383"}],"version-history":[{"count":5,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/383\/revisions"}],"predecessor-version":[{"id":451,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/383\/revisions\/451"}],"wp:attachment":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}