{"id":40,"date":"2010-03-02T18:05:00","date_gmt":"2010-03-02T18:05:00","guid":{"rendered":"http:\/\/lucasgferreira.wordpress.com\/2010\/03\/02\/treinamento-de-forca-e-sintese-proteica-muscular"},"modified":"2010-03-02T18:05:00","modified_gmt":"2010-03-02T18:05:00","slug":"treinamento-de-forca-e-sintese-proteica-muscular","status":"publish","type":"post","link":"https:\/\/blog.ufes.br\/lucasgf\/?p=40","title":{"rendered":"Treinamento de for\u00e7a e s\u00edntese prot\u00e9ica muscular"},"content":{"rendered":"
Ap\u00f3s uma sess\u00e3o de treinamento de for\u00e7a, a taxa de s\u00edntese prot\u00e9ica mostra-se elevada de 2 a 5 vezes em rela\u00e7\u00e3o aos valores de repouso, podendo se estender por at\u00e9 48 horas em indiv\u00edduos alimentados (PHILLIPS et al., 1997). Ap\u00f3s o exerc\u00edcio de for\u00e7a ocorre aumento tanto da s\u00edntese de prote\u00ednas miofibrilares quanto mitocondriais (WILKINSON et al, 2008). Pesquisa recente aponta que a resposta m\u00e1xima na magnitude da s\u00edntese prot\u00e9ica miofibrilar ap\u00f3s este tipo de exerc\u00edcio ocorre entre 60 e 90% de 1RM (KUMAR et al., 2009a). A ativa\u00e7\u00e3o de prote\u00ednas da cascata de sinaliza\u00e7\u00e3o que regulam a inicia\u00e7\u00e3o da tradu\u00e7\u00e3o, como Akt (ou PKB) e mTOR, 4EBP-1, p70S6k e prote\u00edna ribossomal S6, tem sido associada ao aumento da s\u00edntese prot\u00e9ica p\u00f3s-exerc\u00edcio (BAAR e ESSER, 1999; KARLSSON et al, 2004; DREYER et al, 2006; WILKINSON et al, 2008; VOLPI et al, 2008; KUMAR et al, 2009a, MAYHEW et al, 2009). <\/p>\n

<\/a> Entretanto, Kumar et al (2009b), apontam que ainda h\u00e1 evid\u00eancias d\u00fabias quanto \u00e0 rela\u00e7\u00e3o precisa entre a extens\u00e3o das modifica\u00e7\u00f5es nas cascatas de sinaliza\u00e7\u00e3o intracelular e conseq\u00fcentes modifica\u00e7\u00f5es nas taxas de s\u00edntese prot\u00e9ica no m\u00fasculo esquel\u00e9tico em resposta ao exerc\u00edcio f\u00edsico. De fato, Greenhaff et al (2008) recentemente demonstraram que a infus\u00e3o de insulina e amino\u00e1cidos, apesar de provocar aumento significante na fosforila\u00e7\u00e3o da Akt e p70S6k de forma dose dependente, n\u00e3o resultou em aumento concomitante na taxa de s\u00edntese prot\u00e9ica no m\u00fasculo esquel\u00e9tico \u00e0 medida que a dose de insulina era aumentada. Al\u00e9m disso, Wilkinson et al (2008) verificaram que esta via de sinaliza\u00e7\u00e3o foi estimulada tanto pelo exerc\u00edcio de for\u00e7a quanto pelo de resist\u00eancia aer\u00f3bica, apesar da resposta sobre o fen\u00f3tipo do m\u00fasculo esquel\u00e9tico mostrar-se distinta de acordo com o est\u00edmulo. Est\u00e1 claro que se trata de um processo complexo, e que outros fatores est\u00e3o envolvidos nas respostas moleculares ao exerc\u00edcio. \u00c9 prov\u00e1vel que pesquisas posteriores esclare\u00e7am melhor a rela\u00e7\u00e3o temporal e de dose-resposta entre o treinamento de for\u00e7a, express\u00e3o e fosforila\u00e7\u00e3o de vias de sinaliza\u00e7\u00e3o intracelular e a s\u00edntese prot\u00e9ica muscular. <\/p>\n

Refer\u00eancias:<\/span><\/p>\n

Baar K, Esser K. Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol Cell Physiol 276: C120\u2013C127, 1999.<\/p>\n

Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E, Rasmussen BB. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 576: 613\u2013624, 2006.<\/p>\n

Greenhaff PL, Karagounis LG, Peirce N, Simpson EJ, Hazell M, Layfield R, Wackerhage H, Smith K, Atherton P, Selby A, Rennie MJ. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab 295: E595\u2013E604, 2008.<\/p>\n

Karlsson HK, Nilsson PA, Nilsson J, Chibalin AV, Zierath JR, Blomstrand E. Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab 287: E1\u2013E7, 2004.<\/p>\n

Kumar V, Atherton P, Smith K, Rennie MJ. Human muscle protein synthesis and breakdown during and after exercise. J Appl Physiol 106: 2026-2039, 2009b.<\/p>\n

Kumar V, Selby A, Rankin D, Patel R, Atherton P, Hildebrandt W, Williams J, Smith K, Seynnes O, Hiscock N, Rennie MJ. Age-related differences in the dose-response of muscle protein synthesis to resistance exercise in young and old men. J Physiol 587: 211\u2013217, 2009a.<\/p>\n

Mayhew, DL, Kim, J, Cross, JM, Ferrando, AA, Bamman, MM. Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans
J Appl Physiol, November 1, 2009; 107(5): 1655 – 1662.<\/p>\n

Phillips SM, Tipton KD, Aarsland A, Wolf SE, Wolfe RR. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol Endocrinol Metab. 273: E99\u2013E107, 1997.<\/p>\n

Wilkinson SB, Phillips SM, Atherton PJ, Patel R, Yarasheski KE, Tarnopolsky MA, Rennie MJ. Differential effects of resistance and endurance exercise in the fed state on signaling molecule phosphorylation and protein synthesis in human muscle. J Physiol 586: 3701\u20133717, 2008. <\/p><\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Ap\u00f3s uma sess\u00e3o de treinamento de for\u00e7a, a taxa de s\u00edntese prot\u00e9ica mostra-se elevada de 2 a 5 vezes em rela\u00e7\u00e3o aos valores de repouso, podendo se estender por at\u00e9 48 horas em indiv\u00edduos alimentados (PHILLIPS et al., 1997). Ap\u00f3s … Continue lendo →<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_uag_custom_page_level_css":"","footnotes":""},"categories":[6,29,27,36,41],"tags":[],"class_list":["post-40","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-musculacao","category-musculo","category-plasticidade-muscular","category-treinamento"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false},"uagb_author_info":{"display_name":"Lucas Guimar\u00e3es Ferreira","author_link":"https:\/\/blog.ufes.br\/lucasgf\/?author=9"},"uagb_comment_info":9254,"uagb_excerpt":"Ap\u00f3s uma sess\u00e3o de treinamento de for\u00e7a, a taxa de s\u00edntese prot\u00e9ica mostra-se elevada de 2 a 5 vezes em rela\u00e7\u00e3o aos valores de repouso, podendo se estender por at\u00e9 48 horas em indiv\u00edduos alimentados (PHILLIPS et al., 1997). Ap\u00f3s … Continue lendo →","_links":{"self":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/40","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=40"}],"version-history":[{"count":0,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/40\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=40"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=40"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=40"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}