{"id":95,"date":"2010-12-07T12:44:00","date_gmt":"2010-12-07T12:44:00","guid":{"rendered":"http:\/\/lucasgferreira.wordpress.com\/2010\/12\/07\/complexo-mtorc2-e-ativado-por-aminoacidos-pela-via-pi3kakt"},"modified":"2010-12-07T12:44:00","modified_gmt":"2010-12-07T12:44:00","slug":"complexo-mtorc2-e-ativado-por-aminoacidos-pela-via-pi3kakt","status":"publish","type":"post","link":"https:\/\/blog.ufes.br\/lucasgf\/?p=95","title":{"rendered":"Complexo mTORC2 \u00e9 ativado por amino\u00e1cidos pela via PI3K\/Akt."},"content":{"rendered":"
Novas evid\u00eancias acerca da regula\u00e7\u00e3o do mTORC2!<\/span><\/div>\n

<\/span><\/div>\n
<\/span>Amino acids activate mTOR complex 2 via PI3K\/Akt signalling.<\/span><\/div>\n
Tato I<\/a>, Bartrons R<\/a>, Ventura F<\/a>, Rosa JL<\/a>.<\/div>\n
J Biol Chem.<\/span><\/a> 2010 Dec 3. [Epub ahead of print]<\/span><\/span><\/div>\n
Universitat de Barcelona, Spain.<\/div>\n
\n

Abstract<\/h3>\n
The activity of mammalian target of rapamycin (mTOR) complexes regulates essential cellular processes, such as growth, proliferation or survival. Nutrients such as amino acids are important regulators of mTOR Complex 1 (mTORC1) activation, thus affecting cell growth, protein synthesis and autophagy. Here, we show that amino acids may also activate mTOR Complex 2 (mTORC2). This activation is mediated by the activity of class I PI3K and of Akt. Amino acids induced a rapid phosphorylation of Akt at Thr308 and Ser473. Whereas both phosphorylations were dependent on the presence of mTOR, only Akt phosphorylation at Ser473 was dependent on the presence of rictor, a specific component of mTORC2. Kinase assays confirmed mTORC2 activation by amino acids. This signaling was functional, as demonstrated by the phosphorylation of Akt substrate FOXO3a. Interestingly, using different starvation conditions, amino acids can selectively activate mTORC1 or mTORC2. These findings identify a new signaling pathway used by amino acids underscoring the crucial importance of these nutrients in cell metabolism and offering new mechanistic insights.<\/div>\n<\/div>\n
<\/div>\n","protected":false},"excerpt":{"rendered":"

Novas evid\u00eancias acerca da regula\u00e7\u00e3o do mTORC2! Amino acids activate mTOR complex 2 via PI3K\/Akt signalling. Tato I, Bartrons R, Ventura F, Rosa JL. J Biol Chem. 2010 Dec 3. [Epub ahead of print] Universitat de Barcelona, Spain. Abstract The activity of mammalian target … Continue lendo →<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_uag_custom_page_level_css":"","footnotes":""},"categories":[3,6,21,34,40],"tags":[],"class_list":["post-95","post","type-post","status-publish","format-standard","hentry","category-aminoacidos","category-bioquimica","category-fisiologia","category-paper","category-suplementacao"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false},"uagb_author_info":{"display_name":"Lucas Guimar\u00e3es Ferreira","author_link":"https:\/\/blog.ufes.br\/lucasgf\/?author=9"},"uagb_comment_info":9,"uagb_excerpt":"Novas evid\u00eancias acerca da regula\u00e7\u00e3o do mTORC2! Amino acids activate mTOR complex 2 via PI3K\/Akt signalling. Tato I, Bartrons R, Ventura F, Rosa JL. J Biol Chem. 2010 Dec 3. [Epub ahead of print] Universitat de Barcelona, Spain. Abstract The activity of mammalian target … Continue lendo →","_links":{"self":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/95","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=95"}],"version-history":[{"count":0,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=\/wp\/v2\/posts\/95\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=95"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=95"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ufes.br\/lucasgf\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=95"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}